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Alternative 1: Service Teaser

Treatment

Mechanism

Hydroxyurea

Increases fetal hemoglobin production, reducing sickling of red blood cells

Casgevy

Uses CRISPR/Cas9 gene-editing technology to modify patient's stem cells to produce normal hemoglobin

Administration

Hydroxyurea

Oral medication taken daily

Casgevy

One-time intravenous infusion after conditioning therapy

Effectiveness

Hydroxyurea

Reduces frequency of pain crises and need for blood transfusions

Casgevy

Potentially curative, significantly reduces or eliminates pain crises

Side Effects

Hydroxyurea

Bone marrow suppression, increased risk of infections, gastrointestinal issues

Casgevy

Risks associated with gene therapy, including potential for off-target effects and immune reactions

Alternative 2: Text Highlight

Treatment

Mechanism

Hydroxyurea
Increases fetal hemoglobin production, reducing sickling of red blood cells

Casgevy
Uses CRISPR/Cas9 gene-editing technology to modify patient's stem cells to produce normal hemoglobin

Administration

Hydroxyurea
Oral medication taken daily

Casgevy
One-time intravenous infusion after conditioning therapy

Effectiveness

Hydroxyurea
Reduces frequency of pain crises and need for blood transfusions

Casgevy
Potentially curative, significantly reduces or eliminates pain crises

Side Effects

Hydroxyurea
Bone marrow suppression, increased risk of infections, gastrointestinal issues

Casgevy
Risks associated with gene therapy, including potential for off-target effects and immune reactions

Alternative 3: Tiles Visuals

Mechanism

Hydroxyurea

Increases fetal hemoglobin production, reducing sickling of red blood cells

Casgevy

Uses CRISPR/Cas9 gene-editing technology to modify patient's stem cells to produce normal hemoglobin

Administration

Hydroxyurea

Oral medication taken daily

Casgevy

One-time intravenous infusion after conditioning therapy

Effectiveness

Hydroxyurea

Reduces frequency of pain crises and need for blood transfusions

Casgevy

Potentially curative, significantly reduces or eliminates pain crises

Side Effects

Hydroxyurea

Bone marrow suppression, increased risk of infections, gastrointestinal issues

Casgevy

Risks associated with gene therapy, including potential for off-target effects and immune reactions

Alternative 4: Normal Text

Treatment

Mechanism

  • Hydroxyurea
    Increases fetal hemoglobin production, reducing sickling of red blood cells
  • Casgevy
    Uses CRISPR/Cas9 gene-editing technology to modify patient's stem cells to produce normal hemoglobin

Administration

  • Hydroxyurea
    Oral medication taken daily
  • Casgevy
    One-time intravenous infusion after conditioning therapy

Effectiveness

  • Hydroxyurea
    Reduces frequency of pain crises and need for blood transfusions
  • Casgevy
    Potentially curative, significantly reduces or eliminates pain crises

Side Effects

  • Hydroxyurea
    Bone marrow suppression, increased risk of infections, gastrointestinal issues
  • Casgevy
    Risks associated with gene therapy, including potential for off-target effects and immune reactions

Logistics Requirements

Storage

  • Hydroxyurea
  • Casgevy

Distribution

 

Monitoring

 

Specificity

Published: July 2025

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